Category Archives: औषधि परीक्षण

Homoeopathic therapy for lower urinary tract symptoms in men with Benign Prostastic Hyperplasia: An open randomized multicentric placebo controlled clinical trial

Benign Prostatic Hyperplasia (BPH) is the most common condition in ageing men, associated with Lower Urinary Tract Symptoms (LUTS). Being a cause of significant morbidity in ageing man, various observational studies were conducted by the Council with a positive outcome. This protocol has been prepared to further ascertain the usefulness of constitutional/organ remedies in LUTS for men with BPH in a randomized control setting.

Objectives: The primary objective is to compare the changes in IPSS (International Prostate Symptom Score) within the three groups enrolled for the study (Constitutional remedy/Constitutional + Organ remedy/Placebo). The secondary objectives are to compare the changes in Prostate volume, Post Void Residual Urine (PVRU), Uroflowmetry and in WHOQOL-BREF.

Material and Methods: It is an open randomized placebo controlled clinical trial. The prescription of the constitutional remedies/organ remedies/placebo is done as per the randomization chart and the selection of these remedies is done as per the guidelines laid in the Organon of Medicine. The outcome measures including IPSS (monthly), prostate volume, post void residual urine, uroflowmetry and the WHOQOL-BREF are assessed at baseline, three and six months interval.

Discussion:Results from this trial will help in constructing treatment strategy for BPH patients with lower urinary tract symptoms in improving their quality of life.

Trial Registration: Clinical Trial Registry – India: CTRI/2012/05/002649.

Keywords: Homoeopathy, Prostate, Post void residual urine, Prostate volume, Uroflowmetry

Download link : https://app.box.com/s/x2uj1sn304k867fo0exd

Complete Freund’s Adjuvant (CFA) द्वारा गठिया से पीडित किये गये चूहों पर होम्योपैथिक औषधि रस टाक्स के परीक्षण ( Modulation of arthritis in rats by Toxicodendron pubescens and its homeopathic dilutions.)

rats

Source : pubmed & Indian Journal of Research in Homeopathy

पशुऒं पर होम्योपैथिक दवाओं के परीक्षण अधिक देखे नही जाते हैं लेकिन इधर हाल के दिनों मे इन परीक्षणॊं की संख्या बढी है , हाँलाकि यह होम्योपैथिक सिद्दातों का पूर्ण रुप से पालन नही करते इसके बावजूद इनकी महत्ता से इन्कार नही किया जा सकता है । होम्योपैथिक पद्दति मे निशिचित सिद्दांत हैं और उनके लिये लक्षणॊं का लेना और उनके ऊपर प्रेसक्राब करना एक अनिवार्य शर्त है ।

हाँलाकि हाल ही मे The Faculty of Homeopathy २०११जर्नल मे प्रकाशित एक लेख जो पबमेड पर प्रकाशित हुआ कम चर्चा का विषय रहा । पटेल इन्सटिटुयूट आफ़ फ़ारमासियुटिकल रिसर्च के सी.आर. पाटिल , आर.बी.जाधव आदि का लेख रस टाक्स की anti inflammatory property पर था ।

सर्वप्रथम Complete Freund’s Adjuvant (CFA) द्वारा चूहों को गठिया से पीडित किया गया और उसके बाद सिलसिलेवार शुरु हुये  प्रयोगशाला परीक्षण । रस टाक्स के 3cH, 6cH, 30cH, 200cH पोटेन्सी को सफ़लतापूर्वक प्रयोग  कर के उनके परिणामों को होम्योपैथिक मैटैरिया मेडिका आदि मे वर्णित लेखों  के आधार को  सही पाया गया । यह रिसर्च अभी जारी है ।

Modulation of arthritis in rats by Toxicodendron pubescens and its homeopathic dilutions.

Patil CR, Rambhade AD, Jadhav RB, Patil KR, Dubey VK, Sonara BM, Toshniwal SS.

Source

R. C. Patel Institute of Pharmaceutical Education and Research, Karvand Naka, Shirpur 425 405, Dhule, Maharashtra, India.

Abstract
BACKGROUND:

Toxicodendron pubescens P. Mill (Anacardiaceae) known in homeopathy as Rhus toxicodendron (Rhus tox) is used as an anti-inflammatory medicine in homeopathic practice. In this study, Rhus tox in its crude form and homeopathic dilutions (3cH, 6cH, 30cH, 200cH) was evaluated for effects on Complete Freund’s Adjuvant (CFA) induced arthritis in rats.

METHOD:

We assessed the severity of arthritis through observations including inflammatory lesions, body and organ weight and hematological parameters including C-reactive protein (CRP). Blinded radiological analysis of the affected joints and pain intensity determination was also carried out.

RESULTS:

Rhus tox protected rats from CFA-induced inflammatory lesions, body weight changes and hematological alterations. Rhus tox protected against radiological joint alterations due to arthritis. Arthritic pain scores were also favorably affected by Rhus tox. All the dilutions of Rhus tox including crude form showed anti-arthritic activity. The maximum protective effect was evident in the crude form at 10mg/kg/day, by mouth.

CONCLUSION:

This study supports claims in the homeopathic literature on the role of Rhus tox and its ultra dilutions in the treatment of arthritis and associated pain. Further study is needed to explain this anti-arthritic effect of Rhus tox.

pkt 2

Blog Author ( ब्लाग रचयिता ) : डा. प्रभात टन्डन
जन्म भूंमि और कर्म भूमि लखनऊ !! वर्ष १९८६ में नेशनल होम्योपैथिक कालेज , लखनऊ से G.H.M.S. किया , और सन १९८६ से ही इन्टर्नशिप के दौरान से ही प्रैक्टिस मे संलग्न .. वर्ष १९९४ मे P.H.M.S. join करते-२ मन बदला और तब से प्राइवेट प्रैक्टिस मे ………. आगे देखें

पूरक और वैकल्पिक चिकित्सा पद्दतियों और पशु होम्योपैथिक चिकित्सा के पहले डॆटाबेस का शुभारंभ (Launch of CAM Quest Database & Homeopathic Veterinary Database (VetCR))

जर्मनी में हाल ही में Carstens फाउंडेशन ने सीएएम में एक उत्कृष्ट क्लीकिल रिसर्च का ऑनलाइन डेटाबेस शुरू किया है. एक्यूपंक्चर, anthroposophic चिकित्सा, आयुर्वेद, bioenergetics, हर्बल चिकित्सा, होम्योपैथी, मैनुअल चिकित्सा, मन शरीर चिकित्सा और TCM: नौ विभिन्न उपचारोंको को इस अध्ययन मे शामिल किया गया है.
इस डेटाबेस मे जर्मनी  मे होम्योपैथिक केसों की रिपोर्ट की एक बड़ी संख्या शामिल है .वर्तमान में  यह डेटाबेस अंग्रेजी और फ्रेंच में उपलब्ध है,  लेकिन आगे  अन्य यूरोपीय भाषाओं में अनुवाद करने की योजना है.  इस साइट पर जाने के लिये  http://www.cam-quest.org  पर किल्क करें .
पहला होम्योपैथिक पशु चिकित्सा डेटाबेस (VetCR)
पशु चिकित्सा होम्योपैथी के मामले में नैदानिक ​​अनुसंधान के पहले डेटाबेस अब ऑनलाइन उपलब्ध है. मूल पशु चिकित्सा के अध्ययन पर सभी उपलब्ध साहित्य , यादृच्छिक चिकित्सीय परीक्षण, गैर यादृच्छिक चिकित्सीय परीक्षण, पर्यवेक्षणीय अध्ययन, औषधि की प्रूविगं इस साईट पर सुलभता से उपलब्ध है . इस साईट पर जाने के लिये http://www.carstens-stiftung.de/clinresvet/index.php प्रर किल्क करें .

Launch of CAM-QuestDatabase
The Carstens Foundation in Germany has recently launched an excellent online database of clinica lresearch in CAM. Studies in nine different therapies have been included: acupuncture, anthroposophic medicine, ayurveda, bioenergetics, herbal medicine, homeopathy, manual medicine, mind-body medicine and TCM.
The database includes a large number of German homeopathic case reports and provides the facility to perform searches by disease, therapy and study design. The ‘quick search’ function provides a synopsis of studies using the most common therapies for the most common diseases whilst the ‘expert search’ function enables a detailed, comprehensive search across the CAM therapies and full range of diseases within the database.
At present the database is available in English, French, Dutch and German, but there are plans to translate it into all European languages. It is accessible free of charge at  http://www.cam-quest.org
First Homeopathic Veterinary Database (VetCR)
The first database of clinical research in veterinary homeopathy is now accessible online. Containing all available literature on original veterinary studies it provides access to approximately 200 entries of randomised clinical trials, non-randomised clinical trials, observational studies, drug provings, case reports and case series.
Produced by the Carstens Foundation, the database is freely available at [ http://www.carstens-stiftung.de/clinresvet/index.php

Immunology and Homeopathy ( होम्योपैथिक औषधियों की प्रतिरक्षण प्रणाली मे भूमिका )

होम्योपैथी दवाओं की शरीर की प्रतिरक्षण प्रणाली मे क्या भूमिका है , इस संदर्भ मे शोध पत्र हाल ही में आक्सफ़ोर्ड जर्नल मे प्रकाशित हुआ । यह शोध ईटली के department of medicine और sciences  के पौलो बेलवेटी , अनीता कम्फ़ोर्टी और रिचर्ड ओरटॊनी के तत्वधान मे हुआ । ४ भागों मे प्रकाशित यह शोध पत्र होम्योपैथी का इतिहास ,उच्च शक्ति की होम्योपैथिक औष्धियों ( आवोग्रादो सीमा के बाहर ) की  प्रतिरक्षण प्रणाली की सूक्ष्म कोशिकायें पर कार्य , होम्योपैथी दवाओं की पशुओं और पौधों  पर कार्य  और  नैदानिक (clinical ) परीक्षणॊं मे होम्योपैथिक की भूमिका पर प्रकाश डालता हुआ है । संबधित शोध पत्रों को डाउनलोड करने के लिये नीचे दिये लिंक पर चटका लगायें ।

Immunology and Homeopathy. 1. Historical Background  

Immunology and Homeopathy. 2. Cells of the Immune System and Inflammation                                                                       

Immunology and Homeopathy. 3. Experimental Studies on :
Animal Models

Immunology and Homeopathy. 4. Clinical Studies—Part 1 

Immunology and Homeopathy. 4. Clinical Studies—Part 2

Immunology and Homeopathy. 5. The Rationale of the ‘Simile’

Download Link : http://www.box.net/shared/j0d15xxfui

Immunology and Homeopathy. 1. Historical Background
Paolo Bellavite1
, Anita Conforti
2
, Valeria Piasere1
and Riccardo Ortolani
3
1
Department of Scienze Morfologico-Biomediche,
2
Department of Medicina e Sanita ` Pubblica and
3
Association for Integrative Medicine ‘Giovanni Scolaro’, University of Verona, Piazza L.A. Scuro,
37134 Verona, Italy
Homeopathy was born as an experimental discipline, as can be seen from the enormous amount of
homeopathic data collected over more than two centuries. However, the medical tradition of homeo-
pathy has been separated from that of conventional science for a long time. Conventional scientific wis-
dom dictates that homeopathy should have no effect above placebo but experiments on ultra-high
dilutions of solutes together with some clinical data suggest the intriguing possibility that it might do
in some circumstances. Today, an osmotic process between disciplines, previously seen as in conflict,
is facilitated because over the last few decades homeopathy has initiated the methods of current medical
science and a substantial number of experimental studies—at molecular, cellular and clinical levels—are
available. One area of dialogue and of common progress is that of inflammation and immunity, probably
because these are closely related to the traditional ‘vital force’ of the body’s self-healing power. In a
series of papers we review the historical origins of homeopathy, the laboratory and animal models
related to the field of immunopharmacology, the clinical evidence in favor and against the use of homeo-
pathy in the inflammatory diseases and the hypotheses regarding its action mechanism(s). Finally, we
will enlighten the specific characteristics of the homeopathic approach, which places great emphasis
on identifying a cure for the whole organism.
Keywords: Hahnemann – Hippocrates – history of medicine – homeopathy – immunotherapy –
isotherapy – nosodes – Paracelsus – similia principle

  Download : Link 1

 

Immunology and Homeopathy. 2. Cells of the Immune System
and Inflammation
Paolo Bellavite1
, Anita Conforti
2
, Francesco Pontarollo1
and Riccardo Ortolani
3
1
Department of Scienze Morfologico-Biomediche,
2
Department of Medicina e Sanita ` Pubblica and 3
Association
for Integrative Medicine ‘Giovanni Scolaro’, University of Verona, Piazza L.A. Scuro, 37134 Verona, Italy
Here we describe the results of some experimental laboratory studies aimed at verifying the efficacy of
high dilutions of substances and of homeopathic medicines in models of inflammation and immunity.
Studies carried out on basophils, lymphocytes, granulocytes and fibroblasts are reviewed. This approach
may help to test under controlled conditions the main principles of homeopathy such as ‘similarity’ of
drug action at the cellular level and the effects of dilution/dynamization on the drug activity. The current
situation is that few and rather small groups are working on laboratory models for homeopathy. Regard-
ing the interpretation of data in view of the simile principle, we observe that there are different levels of
similarity and that the laboratory data give support to this principle, but have not yet yielded the ultimate
answer to the action mechanism of homeopathy. Evidence of the biological activity in vitro of highly
diluted-dynamized solutions is slowly accumulating, with some conflicting reports. It is our hope that
this review of literature unknown to most people will give an original and useful insight into the
‘state-of-the-art’ of homeopathy, without final conclusions ‘for’ or ‘against’ this modality. This kind
of uncertainty may be difficult to accept, but is conceivably the most open-minded position now.
Keywords: in vitro test – laboratory models – homeopathy – high-dilution – immune system –
basophils – granulocytes – lymphocytes – similia principle

 Download : Link 2

Immunology and Homeopathy. 3. Experimental Studies on
Animal Models
Paolo Bellavite1
, Riccardo Ortolani
2
and Anita Conforti
3
1
Department of Scienze Morfologico-Biomediche,
2
Association for Integrative Medicine ‘‘Giovanni Scolaro’’ and
3
Department of Medicina e Sanita ` Pubblica, University of Verona, Piazza L.A. Scuro, 37134 Verona, Italy
A search of the literature and the experiments carried out by the authors of this review show that there are
a number of animal models where the effect of homeopathic dilutions or the principles of homeopathic
medicine have been tested. The results relate to the immunostimulation by ultralow doses of antigens,
the immunological models of the ‘simile’, the regulation of acute or chronic inflammatory processes
and the use of homeopathic medicines in farming. The models utilized by different research groups
are extremely etherogeneous and differ as the test medicines, the dilutions and the outcomes are
concerned. Some experimental lines, particularly those utilizing mice models of immunomodulation
and anti-inflammatory effects of homeopathic complex formulations, give support to a real effect of
homeopathic high dilutions in animals, but often these data are of preliminary nature and have not
been independently replicated. The evidence emerging from animal models is supporting the traditional
‘simile’ rule, according to which ultralow doses of compounds, that in high doses are pathogenic, may
have paradoxically a protective or curative effect. Despite a few encouraging observational studies,
the effectiveness of the homeopathic prevention or therapy of infections in veterinary medicine is not
sufficiently supported by randomized and controlled trials.
Keywords: homeopathy – immunology – animal models – veterinary homeopathy – similia principle –
ultra-high dilutions – isopathy – homeopathic complexes – paradoxical pharmacology

Download : Link 3

Immunology and Homeopathy. 4. Clinical Studies—Part 1
Paolo Bellavite1
, Riccardo Ortolani
2
, Francesco Pontarollo1
, Valeria Piasere1
,
Giovanni Benato2
and Anita Conforti
3
1
Department of Scienze Morfologico-Biomediche,
2
Association for Integrative Medicine ‘Giovanni Scolaro’ and
3
Department of Medicina e Sanita ` Pubblica, University of Verona, Piazza L.A. Scuro, 37134 Verona, Italy
The evidence-based research of the effectiveness of homeopathic medicines in common immunologic
disorders is reviewed. In part 1, we introduce methodological issues of clinical research in homeopathy,
and criteria utilized to evaluate the literature. Then 24 studies (12 randomized and 12 non-randomized)
on common upper respiratory tract infections and otorhinolaryngologic complaints are described. In part
2, the focus will be on allergic diseases and the effectiveness of homeopathy will be globally evaluated
and discussed using the criteria of evidence-based medicine.
Keywords: evidence-based homeopathy – homeopathy – homeopatic medications – immunology –
otitis – sinusitis – stomatitis – upper respiratory tract infections

Download : Link 4

Immunology and Homeopathy. 4. Clinical Studies—Part 2

Paolo Bellavite1
, Riccardo Ortolani
2
, Francesco Pontarollo1
, Valeria Piasere1
,
Giovanni Benato2
and Anita Conforti
3
1
Department of Scienze Morfologico-Biomediche,
2
Association for Integrative Medicine ‘Giovanni Scolaro’ and
3
Department of Medicina e Sanita ` Pubblica, University of Verona, Piazza L.A. Scuro, 37134 Verona, Italy
The clinical studies on the effectiveness of homeopathy in respiratory allergy (18 randomized trials
and 9 observational studies) are described. The literature of common immunologic disorders including
also upper respiratory tract infections (URTI) and otorhinolaryngology (reported in part 1), is evaluated
and discussed. Most of initial evidence-based research was addressed to the question of whether
homeopathic high dilutions are placebos or possess specific effects, but this question has been often
equivocal and is still a matter of debate. The evidence demonstrates that in some conditions homeopathy
shows significant promise, e.g. Galphimia glauca (low dilutions/potencies) in allergic oculorhinitis,
classical individualized homeopathy in otitis and possibly in asthma and allergic complaints, and a few
low-potency homeopathic complexes in sinusitis and rhinoconjunctivitis. A general weakness of
evidence derives from lack of independent confirmation of reported trials and from presence of
conflicting results, as in case of homeopathic immunotherapy and of classical homeopathy for URTI.
The suitable methods to evaluate homeopathy effectiveness, without altering the setting of cure, are also
analyzed.
Keywords: allergy – asthma – evidence-based homeopathy – homeopathic immunotherapy –
homeopathic medications – homeopathy – immunology – isopathy – rhinoconjunctivitis

Download : Link 5

Immunology and Homeopathy. 5. The Rationale of the ‘Simile’

Paolo Bellavite1
, Riccardo Ortolani
2
, Francesco Pontarollo1
, Giuseppina Pitari
3
and Anita Conforti
4
1
Department of Scienze Morfologico-Biomediche, University of Verona, Piazza L. A. Scuro, 37134 Verona,
2
Association for Integrative Medicine ‘Giovanni Scolaro’,
3
Department of Basic and Applied Biology,
University of L’Aquila and 4
Department of Medicina e Sanita ` Pubblica, University of Verona, Italy
The foundation of homeopathic medicine is the ‘Similia Principle’, also known as the ‘Principle
of Similarity’ or also as the ‘Simile’, which reflects the inversion of pharmacological effects in
healthy subjects as compared with sick ones. This article describes the inversion of effects, a
widespread medical phenomenon, through three possible mechanisms: non-linearity of dose–
response relationship, different initial pathophysiological states of the organism, and
pharmacodynamics of body response to the medicine. Based on the systemic networks which
play an important role in response to stress, a unitary and general model is designed:
homeopathic medicines could interact with sensitive (primed) regulation systems through
complex information, which simulate the disorders of natural disease. Reorganization of
regulation systems, through a coherent response to the medicine, could pave the way to the
healing of the cellular, tissue and neuro-immuno-endocrine homeodynamics. Preliminary
evidence is suggesting that even ultra-low doses and high-dilutions of drugs may incorporate
structural or frequency information and interact with chaotic dynamics and physical-
electromagnetic levels of regulation. From the clinical standpoint, the ‘simile’ can be regarded
as a heuristic principle, according to which the detailed knowledge of pathogenic effects of
drugs, associated with careful analysis of signs and symptoms of the ill subject, could assist
in identifying homeopathic remedies with high grade of specificity for the individual case.

Keywords: action–reaction principle – biologic networks – homeopathic medicine – hormesis –
inverse effects – paradoxical pharmacology – response to stress – self-organization – Similia
principle –Wilder’s rule

Download : Link 6

क्या रुटा मस्तिषक अर्बुद्द (Brain Tumour) के रोगियों के लिये वरदान साबित होगी ?

आरम्भिक परिणाम तो कुछ –२ इसी तरफ़ इशारा कर रहे हैं । हाल ही मे स्पेन और कोलम्बिया यूनिवर्सटी से आये दो अलग-२ दलों ने कोलकाता के डा. प्रशान्त बैनर्जी कैन्सर रिसर्च सेन्टर ,  मे आ कर कैन्सर मे होम्योपैथिक दवाओं के परिणामों  की जानकारी और अध्यनन किया । कोलम्बिया यूनिवर्सीटी ने तो फ़िलहाल पिछले साल से इस सेन्टर से अनुबंध भी कर रखा है । देखे यहाँ और यहाँ

लेकिन बात रूटा और कोलकाता के डा. प्रशान्त बैनर्जी कैन्सर रिसर्च सेन्टर की । कुछ साल पहले पबमेड पर प्रकाशित एक रिसर्च पेपर ने कैन्सर से जुडॆ कई शोध संस्थान और स्वंयसेवी संस्थाऒं का ध्यान आकृष्ट किया । डा प्रशान्त बैनर्जी का तरीका हाँलाकि क्लासिकल होम्योपैथों को भले ही रास न आये क्योंकि यह होम्योपैथी के मूलभूत सिद्दातों के खिलाफ़ है , फ़िर भी मिलने वाले परिणाम होम्योपैथी मे एक नये युग की शुरुआत अवशय कर सकते हैं । प्रिसक्राबिग का तरीका आसान है और मूलत: disease diagnosis पर ही आधारित है जब कि क्लासिकल होम्योपैथी रोगी को संम्पूर्ण रूप से लेकर चलती है।। नीचे देखें साउथ कैलीफ़ोर्निया यूनीवर्सिटी  की एक कान्फ़्रेन्स मे प्रशान्त अपने तरीकों को श्रोतागणों को समझाते हुये । रुटा से संबधित डा. प्रशान्त बैनर्जी के इस लेख को आप यहाँ भी देख सकते है । रूटा पर चल रहे क्लीनीकल परीक्षण की जानकारी के लिये यहाँ देखें ।

अब रुटा के ऊपर चर्चा कर ली जाये । दक्षिण अमेरिका मे पाये जाने वाले इस पौधे की गाछ से इसका टिन्चर तैयार किया जाता है । होम्योपैथी मैटेरिया मेडिका और रिपर्टिरी मे इसका उल्लेख कैन्सर मे नही है । मूलत: इस दवा का उपयोग काँच निकलने ( prolapse rectum), रात मे अनजाने पेशाब हो जाने पर ( nocturnal enuresis) ,शरीर के किसी भी स्थान पर चोट लगने के बाद प्रदाह ( synovitis) होने पर , बहुत से शल्य चिकित्सा वाले उपसर्गों मे  रुटा उपयोगी होता है विशेषकर अस्थि आवरक झिल्ली की तकलीफ़ जहाँ   हड्डी पर का माँस कम  रहता है जैसे टिबीया (Tibia)  । कुचले हुये स्थान का दर्द चला जाता है लेकिन एक कडी जगह छोड जाता है । रुटा रस टाक्स के कई अर्थों मे सदृश है , विशेषकर ठन्डक से रोगी का असहिष्णु रहना और शीतकाल मे रोग का बढना । लेकिन हकीकत मे इस दवा की परीक्षा उतनी नही हुयी । मैटेरिया मेडिका मे कैन्सर से संबधित कोई भी उल्लेख न होने पर यह अवशय ताज्जुब लगता है कि रुटा का प्रयोग कैन्सर मे डा. प्रशान्त बैनर्जी  ने क्यों किया ।

Anti-tumour activity of Ruta graveolens extract.
source:  Pubmed
Preethi KC, Kuttan G, Kuttan R.

Amala Cancer Research Centre, Amala Nagar, Thrissur, Kerala-680555, India.

An extract of Ruta graveolens was found to be cytotoxic to Dalton’s lymphoma ascites (DLA), Ehrlich ascites carcinoma (EAC) and L929 cells in culture (IC100=16 mg/ml) and also to increase the lifespan of tumour bearing animals. The extract further decreased solid tumours developing from DLA and EAC cells when given simultaneously with elongation of the lifespan of tumour-bearing animals. A homeopathic preparation of Ruta graveolens (200 c) was equally effective. Neither was effective for reducing already developed tumours. The Ruta graveolens extract was found to scavenge hydroxyl radicals and inhibit lipid peroxidation at low concentrations. However, at higher concentrations the extract acted as a prooxidant as inhibition of lipid peroxidation and scavenging of hydroxyl radical was minimal. These data indicates that the prooxidant activity of Ruta graveolens may be responsible for the cytocidal action of the extract and its ability to produce tumour reduction.

 

Ruta 6 selectively induces cell death in brain cancer cells but proliferation in normal peripheral blood lymphocytes: A novel treatment for human brain cancer.
Source : PubMed

Pathak S, Multani AS, Banerji P, Banerji P.

Department of Molecular Genetics, M.D. Anderson Cancer Center, Houston, TX 77030, USA. pathak_sen@yahoo.com

Although conventional chemotherapies are used to treat patients with malignancies, damage to normal cells is problematic. Blood-forming bone marrow cells are the most adversely affected. It is therefore necessary to find alternative agents that can kill cancer cells but have minimal effects on normal cells. We investigated the brain cancer cell-killing activity of a homeopathic medicine, Ruta, isolated from a plant, Ruta graveolens. We treated human brain cancer and HL-60 leukemia cells, normal B-lymphoid cells, and murine melanoma cells in vitro with different concentrations of Ruta in combination with Ca3(PO4)2. Fifteen patients diagnosed with intracranial tumors were treated with Ruta 6 and Ca3(PO4)2. Of these 15 patients, 6 of the 7 glioma patients showed complete regression of tumors. Normal human blood lymphocytes, B-lymphoid cells, and brain cancer cells treated with Ruta in vitro were examined for telomere dynamics, mitotic catastrophe, and apoptosis to understand the possible mechanism of cell-killing, using conventional and molecular cytogenetic techniques. Both in vivo and in vitro results showed induction of survival-signaling pathways in normal lymphocytes and induction of death-signaling pathways in brain cancer cells. Cancer cell death was initiated by telomere erosion and completed through mitotic catastrophe events. We propose that Ruta in combination with Ca3(PO4)2 could be used for effective treatment of brain cancers, particularly glioma.

कुछ नयी होम्योपैथिक औषधियों के औषधि परीक्षण-1 (The Provings of new Homeopathic Remedies-1)

  होम्योपैथिक औषधियों के परीक्षण स्वस्थ मनुषयों पर किये जाते हैं । इधर हाल के दिनों मे कई नई औषधियों का समावेश हुआ है , यह बात कि अलबत्ता कि यह भारत मे उपलब्ध नहीं है । टन्ब्रिज वेल्स , केन्ट की हिलोऐस फ़ार्मेसी इन औषधियों के अधिकृत विक्रेता हैं ।

 


Go to the AIDS proving.

The AIDS Nosode

The nosode prepared from the blood of a man diagnosed as having Acquired Immune Deficiency Syndrome who subsequently died of Syndrome related diseases.

Conducted by Misha Norland at The School of Homœopathy in 1994 and 1995.

Go to the Falco proving.

Falco Peregrinus Disciplinatus

Trained Peregrine Falcon

A remedy prepared from the blood and feather of a Peregrine Tiercel who had been bred in captivity and trained to hunt in the traditional manner.

Conducted by Misha Norland at
The School of Homœopathy in 1997.

Go to the Positronium proving.

Positronium

Antimatter

The radiation produced in the annihilation of Positronium atoms.

Conducted by Misha Norland at The School of Homœopathy in 1998.


Go to the Dreaming Potency proving.

Dreaming Potency

A remedy prepared from a medicine given to Janet Snowdon by Sangomas in South Africa.

Conducted by Janet Snowdon in Bath in 1996.


Go to the Proving of Kauri.

Agathis Australis

Kauri

A remedy prepared from the gum of the magnificent Kauri tree of New Zealand.

Conducted by Misha Norland
at The School of Homœopathy.


Go to the Proving of Lava.

Lava

Basaltic Lava from Flagstaff Arizona.

Conducted by Misha Norland at The School of Homœopathy


Go to the Proving of Crack Willow.

Salix fragilis

Crack Willow

Conducted by Penny Stirling in Bristol in 1998.

Go to the Proving of North Wales Slate.

North Wales Slate

Conducted by Misha Norland in Czechoslovakia
and by Andy Brachi and Jenny Hill in North Wales

Summer 1996

Go to the Proving of
Knopper Oak Galls

Knopper Oak Gall

Gall on Quercus pendunculata caused by the wasp Cynips calicis.

Conducted by Misha Norland in Moravia in 1998.

Go to the Proving of
LSD-25

LSD-25

D-Lysergic Acid Diethylamide

Conducted by Misha Norland
at The School of Homœopathy in 1999.

Go to the Proving of Heroin

Heroin

Dia-morphione

Conducted by Janet Snowdon in 1999 and 2000

Go to the Proving of Reindeer Moss

Reindeer Moss

Cladonia rangiferina

Conducted by Misha Norland
at the School of Homœopathy in 2000

Go to the Proving of Bewick Swan

Cygnus Bewickii

The Bewick Swan

Conducted by Penny Stirling in Bristol 2002

Go to the Proving of Rubber

Latex vulcani

Vulcanized Rubber prepared from a natural latex condom.

Conducted by Misha Norland and Peter Fraser
at The School of Homœopathy in 2001

Go to the Proving of Buckyballs

Carbo Fullerenum

Buckyballs or Carbon 60

Conducted by Misha Norland and Peter Fraser
at The School of Homœopathy in 2002

Go to the Proving of Galium Aparine

Galium aparine

Cleavers or Goosegrass

Conducted by Misha Norland and Peter Fraser
at The School of Homœopathy in 2003

Go to the Proving of Passer domesticus

Passer domesticus

The House Sparrow

Conducted by Misha Norland and Peter Fraser
at the School of Homœopathy in 2004

Go to the Proving of
Pavo Cristatus

Pavo cristatus

Peacock Feather

Conducted by Peter Fraser
and members of The Homœopathic Development and Research Centre Kathmandu, Nepal in 2005

Go to the Proving of
Blatta orientalis

Blatta orientalis

Cockroach

Conducted by Dr. Munjal Thakar
in Bombay in 1995

Provings now being Collated

Provings whose results are now being collated and prepared for publication on this site include:

Aqua nova

Conducted by Misha Norland and Peter Fraser
at the School of Homœopathy in 2006

Amphisbaena alba

Conducted by Misha Norland
at the School of Homœopathy in 2001

The Provings of New Homœopathic Remedies

The texts of the following provings are available on this site or are in the process of being compiled. Each proving includes the symptoms as recorded by the provers or their supervisors, an introduction by the proving’s organizer and other information about the substance, a repertorization and details of cured cases.

Creative Commons License
These provings are licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 2.5 License.

Obtaining Remedies

All these provings were conducted with Remedies that are available from Helios Homœopathic Pharmacy in Tunbridge Wells, Kent, England. Helios is both knowledgeable about and supportive of the proving of new remedies.

Go to the Helios Website at www.helios.co.uk