Role of homoeopathic mother tinctures in rheumatoid arthritis: An experimental study – रुमेटाइड संधिशोध मे होम्योपैथिक मदर टिन्चरों की भूमिका

arthritic_joints

हाल ही में दो शोध पत्र प्रस्तुत हुये । एक IJRH के जर्नल में और दूसरे pub med पर पब्लिश हुये । पहले शोध पत्र मे होम्योपैथिक मदर टिन्चर जैसे Ricinus communis (RCMT), Rauwolfia serpentina (RSMT), Bellis perennis (BPMT), Curcuma longa(CLMT), Terminalia arjuna (TAMT) and Tribulus terresteris (TTMT और दूसरे शोध पत्र मे होम्योपैथिक टिन्चर Guaiacum officinale के शोधरोधी , वेदनाहार और संधिशोधरोधी प्रभाव का अध्ययन करना था ।

दोनों ही प्रयोगों के लिये एल्बीनों चूहों का प्रयोग प्रायोगिक अध्ययन के लिये किया गया । सामान्य लक्षण विलयन में 1% कैरागीनन की 0.1 ml की मात्रा दायें पंजे मे दे कर शोध प्रेरित किया गया । सोध की मात्रा का आंकलन पंजे की सूजन के आधार पर किया गया । विस्टर एल्बीनो चूहों के प्रपद तलवे में पूर्ण फ़्रायन्ड सह औषध ( CFA ) इंजेक्शन लगाकर संधिशोध प्रेरित किया गया ।

परिणाम:

कुरकुमा लौंगा और ट्राइव्यूलस टरेसटेरिस और ग्वायकम आफ़ मातृ टिन्चर द्वारा कैरागीनन उपचारित चूहों के पाश्च पंजे के सूजन मे कमी आयी आऊ पंजे का आयतन घटा ।यह शक्तिशाली शोधरोधी सक्रियता को दर्शाता है । सभी होम्योपैथिक मातॄ टिन्चर ने चूहों में उष्ण प्रेरित तापीय वेदना में भी परिधीय वेदनाहार सक्रियता दिखाई ।

Role of homoeopathic mother tinctures in rheumatoid arthritis: An experimental study
Surender Singh1, Ritu Karwasra1, Prerna Kalra1, Rohit Kumar1, Shalu Rani1, Debadatta Nayak2, YK Gupta1
1 Department of Pharmacology, All India Institute of Medical Sciences, New Delhi, India
2 Central Council for Research in Homoeopathy, New Delhi, India
Abstract
Objectives: The objective of present preliminary study was to assess the anti-inflammatory, analgesic and anti-arthritic effect of some homoeopathic mother tinctures viz. Ricinus communis (RCMT), Rauwolfia serpentina (RSMT), Bellis perennis (BPMT), Curcuma longa(CLMT), Terminalia arjuna (TAMT) and Tribulus terresteris (TTMT).
Materials and Methods: Paw oedema was induced by administration of 0.1ml 1% carrageenan in normal saline into right hind paw. Degree of inflammation was evaluated according to paw swelling. Arthritis was induced by Complete Freund’s Adjuvant (CFA) injection in metatarsal footpad of Wistar albino rats.
Result: Curcuma longa and Tribulus terresteris mother tinctures reduced hind paw swelling decreased the paw volume in Carrageenan treated rats. Thus, revealed potent activity against inflammation. All homoeopathic mother tinctures showed peripheral analgesic activities in hot plate induced thermal algesia in mice.

Download Link : http://www.ijrh.org/text.asp?2015/9/1/42/154348
Source : Indian Journal of Research in Homeopathy

Anti-rheumatoid and anti-oxidant activity of homeopathic Guaiacum officinale in an animal model.

Sarkar A1, Datta P1, Das AK1, Gomes A2.

Author information
Abstract
BACKGROUND:

Homeopathy is a popular form of complementary and alternative medicine. Guaiacum extract is said to be useful for pain and inflammation, but there appears to be no scientific evidence to support this.

AIMS:

The aim of the present study was to evaluate the anti-rheumatic and anti-oxidant activity of homeopathic preparations of Guaiacum officinale (Gua) on experimental animal model.

DESIGN:

Rheumatoid arthritis (RA) was induced in male albino rats by Freund’s complete adjuvant (FCA) at a dose of (0.25 mg heat killed Mycobacterium tuberculosis/ml of emulsion). Gua mother tincture (MT) (prepared from the latex part of the plant) (MT), Gua 30cc and 200cc were purchased commercially from King Company, Kolkata, India. Male albino Wistar rats (130 ± 10 g) were divided into 6 groups: Sham control; Arthritis control; Standard treatment indomethacin (0.25 mg 100 g(-1) p.o. × 5 alternative days), Gua MT (1 ml kg(-1) p.o. × 5 days) treated; Gua (30c 1 ml kg(-1) p.o. × 5 days) treated; Gua (200c; 1 ml kg(-1) p.o. × 5 days) treated. Anti-rheumatic activity was examined through physical, urinary, serum parameters. All the results were expressed in terms of mean ± SEM (statistical error of mean n = 6) at each dose level. The level of significance was determined through one-way analysis of variance (ANOVA), p < 0.05 was considered significant.

RESULTS:

It was observed that body weight, ankle and knee diameter, urinary parameters (hydroxyproline (OH-P), glucosamine, calcium (Ca(2)(+)), creatinine (CRE), phosphate (PO4(3)(-))), serum ACP (acid phosphatase)/ALP (alkaline phosphatase)/Ca(2+)/CRE/PO4(3-)/gamma-glutamyl transferase (GGT)/Lipid peroxidation (LPO)/Glutathione (GSH)/Superoxide dismutase (SOD)/Catalase, serum GGT, serum interleukins like IL-1β/CINC-1/PGE2/TNF-α/IL-6, IL-12/IL-4/IL-6 levels were significantly affected. After treatment with Guaiacum in all 3 regimes was associated with normalization of these parameters compared to control group.

CONCLUSION:

These findings suggest that homeopathic G. officinale possesses anti-rheumatic and anti-oxidant activity in experimental animal and these activities may be more significant in higher potencies.

Download Link : http://www.ncbi.nlm.nih.gov/pubmed/24685418

Source : Pubmet

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